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“The concept of lung fibroblasts as effector cells in the pathogenesis of idiopathic pulmonary fibrosis ( IPF ) has recently evolved [ 1 2 ] . Lung fibroblasts respond , in vitro , to inflammatory cytokines by producing growth factors and collagen , resulting in fibroblast proliferation and extracellular matrix deposition [ 2 3 4 ] . In addition , activated lung fibroblasts have been shown to produce large amounts of inflammatory cytokines and chemokines , in vitro , and hence , these cells may also have a role as effector-inflammatory cells [ 1 2 ] . This capacity to produce both inflammatory and fibrotic factors could mean that phenotypically altered lung fibroblasts act simultaneously as effector and target cells , via paracrine and autocrine mechanisms , perpetuating the fibrotic process [ 2 ] .”
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| Is lemon:example of | FN_Sense_7204 More... |
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